Effects of Ethanol on the Supercritical Carbon Dioxide Extraction of Cannabinoids from Near Equimolar (THC and CBD Balanced) Cannabis Flower

In this study, supercritical carbon dioxide (scCO2) extractions of cannabinoids were conducted at four different densities (231, 590, 818, and 911 kg/m3) using ethanol (5% w/v) as a co-solvent. The chemical profiles these analysed via reverse-phase high-performance liquid chromatography (RP-HPLC). It was determined that scCO2, low density (231 kg/m3), produced an extract yield 6.1% w/v. At high scCO2 (~818 the 16.1% More specifically, amounts tetrahydrocannabinol (THC) cannabidiol (CBD) in 818 kg/m3 10.8 15.6% w/v, respectively. also found use 5% w/v increased yields both (7.6% 18.2% respectively). Additionally, co-solvent further under low- high-density conditions, to 13.7 19.1% Interestingly, higher (911 with without did not improve or amount cannabinoids. Although study provides new insights into correlation between co-extraction CBD THC, more studies are needed determine how co-solvents influence extraction